The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, dihydrochloride


RTECS #: ST0350000

CAS #: 624-18-0

UPDATE: April 1999 MW: 181.08 MF: C6H8N2•2ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. p - Aminoaniline dihydrochloride
  2. 4 - Aminoaniline dihydrochloride
  3. p - Benzenediamine dihydrochloride
  4. 1,4 - Benzenediamine dihydrochloride
  5. C.I. 76061
  6. C.I. Oxidation Base 10A
  7. p - Diaminobenzene dihydrochloride
  8. 1,4 - Diaminobenzene dihydrochloride
  9. Durafur Black RC
  10. Fourrine 64
  1. Fourrine DS
  2. NCI - C03930
  3. Oxidation Base 10A
  4. p - PD HCl
  5. p - Pda HCl
  6. Pelagol CD
  7. Pelagol Grey CD
  8. 1,4 - Phenylenediamine dihydrochloride
  9. p - Phenylenediamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 333 µg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms mouse lymphocyte 31,300 µg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 33,300 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in mammalian somatic cells human lymphocyte 20 mg/L MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 1,250 µg/L EMMUEG 12(Suppl 13),103,1988
specific locus test oral
Drosophila melanogaster 		500 µmol/L MUREAV 341,161,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 316 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rat 		lethal dose (50 percent kill): 147 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
subcutaneous
dog 		lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
frog 		lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
mouse 		lowest published lethal dose: 50 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
rabbit 		lowest published lethal dose: 20 mg/kg N/R XPHBAO 271,42,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,125,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-174,1979


REFERENCES:

CODEN
REFERENCE
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)




RTECS Compound Description:
   Tumorigen
   Mutagen