The Registry of Toxic Effects of Chemical Substances (RTECS)

The Registry of Toxic Effects of Chemical Substances

Ether, fluoromethyl 2,2,2 - trifluoro - 1 - (trifluoromethyl) ethyl -

RTECS #: KO0737000

CAS #: 28523-86-6

UPDATE: July 2002 MW: 200.07 MF: C₄H₃F₇O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

REFERENCES:

SYNONYMS:

1,1,1,3,3,3 - Hexafluoro - 2 - (fluoromethoxy) propane

Fluoromethyl 2,2,2 - trifluoro - 1 - (trifluoromethyl) ethyl ether

Fluoromethyl - 1,1,1,3,3,3 - hexafluoro - 2 - propyl ether

MR6S4

Propane, 1,1,1,3,3,3 - hexafluoro - 2 - (fluoromethoxy) - (9CI)

SVF

Sevoflurane

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA damage inhalation
human 1 pph/2 hour MUREAV 492,99,2001
micronucleus test oral
rat 4 mmol/kg MUREAV 413,1,1998

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
rat lowest published toxic concentration: 6,600 ppm/3 hour (64 day male/14 day prior to copulation) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands KSRNAM 21,5505,1987
inhalation
rat lowest published toxic concentration: 2 pph/3 hour (9 week male/2 week prior to copulation/1-7 day pregnant) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) KSRNAM 21,5505,1987
inhalation
rat lowest published toxic concentration: 1 pph/3 hour (9 week male/2 week prior to copulation/1-7 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system KSRNAM 21,5505,1987

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mouse lethal concentration (50 percent kill): 28,300 ppm/3 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis

Skin and Appendages: Other: Hair KSRNAM 21,5497,1987
inhalation
rat lethal concentration (50 percent kill): 28,800 ppm/3 hour Behavioral: Tremor

Lung, Thorax, or Respiration: Cyanosis

Skin and Appendages: Other: Hair KSRNAM 21,5497,1987
intraperitoneal
mouse lethal dose (50 percent kill): 10,500 mg/kg N/R NIIRDN -,591,1990
intraperitoneal
rat lethal dose (50 percent kill): 6,300 mg/kg N/R NIIRDN -,591,1990
oral
mouse lethal dose (50 percent kill): 18,200 mg/kg N/R NIIRDN -,591,1990
oral
rat lethal dose (50 percent kill): 10,800 mg/kg N/R NIIRDN -,591,1990

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

N/R N/R N/R

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector