The Registry of Toxic Effects of Chemical Substances

Ethanol, 2 - (2 - (2 - ethoxyethoxy) ethoxy) -


RTECS #: KK8950000

CAS #: 112-50-5

UPDATE: February 2003 MW: 178.26 MF: C8H18O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Dowanol TE
  2. 2 - (2 - (2 - Ethoxyethoxy) ethoxy) ethanol
  3. Ethoxytriethylene glycol
  4. Ethoxytriglycol
  5. Poly - Solv TE
  1. Triethylene glycol ethyl ether
  2. Triethylene glycol monoethyl ether
  3. Triglycol monoethyl ether
  4. 3,6,9 - Trioxaundecanol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg mild AJOPAA 29,1363,1946


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lethal dose (50 percent kill): 3,070 mg/kg N/R VCVGK* -,175,1984
oral
mouse 		lethal dose (50 percent kill): 5,798 mg/kg N/R VCVGK* -,175,1984
oral
rat 		lethal dose (50 percent kill): 7,750 mg/kg N/R VCVGK* -,175,1984
skin
rabbit 		lethal dose (50 percent kill): 8 mL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 141 mg/kg/26 week- intermittent Blood: Changes in leukocyte (WBC) count

Blood: Changes in platelet count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 47(5),84,1982
oral
rat 		lowest published toxic dose: 930 mg/kg/30 day- intermittent Blood: Normocytic anemia

Blood: Changes in erythrocyte (RBC) count 		VCVGK* -,175,1994
oral
rat 		lowest published toxic dose: 141 mg/kg/26 week- intermittent Blood: Changes in cell count (unspecified)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		VCVGK* -,175,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2556;
Number of Industries 83;
Total Number of Facilities 12,848;
Number of Occupations 25;
Total Number of Employees Exposed 81,218
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2556;
Number of Industries 3;
Total Number of Facilities 70;
Number of Occupations 3;
Total Number of Employees Exposed 621;
Total Number of Female Employees Exposed 44


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.




RTECS Compound Description:
   Primary Irritant