The Registry of Toxic Effects of Chemical Substances

Ethane, 1,1 - dichloro -


RTECS #: KI0175000

CAS #: 75-34-3

UPDATE: November 2004 MW: 98.96 MF: C2H4Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 1,1 - Dichloorethaan (Dutch)
  2. 1,1 - Dichloraethan (German)
  3. 1,1 - Dichlorethane
  4. 1,1 - Dichloroethane
  5. 1,1 - Dichloroethane (ACGIH:OSHA)
  6. 1,1 - Dicloroetano (Italian)
  7. Aethylidenchlorid (German)
  1. Chlorinated hydrochloric ether
  2. Chlorure d'ethylidene (French)
  3. Cloruro di etilidene (Italian)
  4. Ethylidene chloride (OSHA)
  5. Ethylidene dichloride
  6. NCI - C04535
  7. RCRA waste number U076


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 13 mmol/L MUREAV 221,263,1989
sex chromosome loss and nondisjunction Aspergillus nidulans 2,000 ppm MUREAV 201,401,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 6,000 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 28,452,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 185 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-66,1978
oral
mouse 		toxic dose : 1,300 gm/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-66,1978


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 30,000 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,355,1990
inhalation
mouse 		lowest published lethal concentration: 70,000 mg/m3/2 hour N/R VCVGH* -,355,1990
inhalation
rat 		lethal concentration (50 percent kill): 13,000 ppm/4 hour N/R NTIS** AD-A180-198
oral
rat 		lethal dose (50 percent kill): 725 mg/kg N/R HYSAAV 32(3),349,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 240 gm/kg/12 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TOXID9 6,313,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 100 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AIHAAP 40(3),A46,1979
TOXICOLOGY REVIEW
NTIS** PB82-182809
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 200 ppm (320 mg/m3) DTLWS* 3,15,1973
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 100 ppm (400 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 200 ppm (810 mg/m3), short term exposure limit 250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (400 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 200 ppm (810 mg/m3), short term exposure limit 250 ppm (1010 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (400 mg/m3), short term exposure limit 250 ppm (1000 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 200 ppm (810 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (400 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (400 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 400 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit - POLAND time-weighted average 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 100 ppm, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (400 mg/m3), KZG- week 200 ppm (800 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 50 ppm, short term exposure limit 100 ppm, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (400 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 200 ppm (823 mg/m3), short term exposure limit 400 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO 1,1-DICHLOROETHANE-air 10 hour time-weighted average 100 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24120;
Number of Industries 7;
Total Number of Facilities 143;
Number of Occupations 9;
Total Number of Employees Exposed 715
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24120;
Number of Industries 2;
Total Number of Facilities 10;
Number of Occupations 7;
Total Number of Employees Exposed 1,957;
Total Number of Female Employees Exposed 272


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/91/180539/AS)
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 27, 1978
NIOSH Analytical Method, 1994: Hydrocarbons, halogenated, 1003
NCI Carcinogenesis Bioassay (gavage);equivocal evidence:mouse,rat NCITR* NCI-TR-66,1978


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTLWS* "Documentation of the Threshold Limit Values for Substances in Workroom Air," Supplements. For publisher information, see 85INA8.
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.




RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector