The Registry of Toxic Effects of Chemical Substances

Benzenethiol


RTECS #: DC0525000

CAS #: 108-98-5

UPDATE: November 2004 MW: 110.18 MF: C6H6S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Mercaptobenzene
  2. Phenol, thio -
  3. Phenyl mercaptan
  4. Phenyl mercaptan (ACGIH:OSHA)
  1. RCRA waste number P014
  2. Thiofenol (Czech)
  3. Thiophenol
  4. USAF XR - 19


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		108 mg severe AIHAAP 19,171,1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus 		NTIS** PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Other effects on female NTIS** PB94-155009
oral
rat 		lowest published toxic dose: 18 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 18 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 315 mg/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 5,145 mg/kg (21 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 9 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 9 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** #PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus NTIS** #PB94-155009


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 28 ppm/4 hour Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation 		AIHAAP 19,171,1958
inhalation
rat 		lethal concentration (50 percent kill): 33 ppm/4 hour Lung, Thorax, or Respiration: Respiratory stimulation

Behavioral: Somnolence (general depressed activity)

Eye: Lacrimation 		AIHAAP 19,171,1958
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 9,800 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		AIHAAP 19,171,1958
oral
wild bird 		lethal dose (50 percent kill): 24 mg/kg N/R TXAPA9 21,315,1972
oral
mouse 		lethal dose (50 percent kill): 267 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Hypermotility, diarrhea 		NTIS** OTS0557376
oral
mouse 		lethal dose (50 percent kill): 266 mg/kg N/R GISAAA 1,7,1994
oral
rat 		lethal dose (50 percent kill): 46,200 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		AIHAAP 19,171,1958
oral
rat 		lethal dose (50 percent kill): 223 mg/kg N/R GISAAA 1,7,1994
skin
rat 		lethal dose (50 percent kill): 300 mg/kg Behavioral: Tremor

Lung, Thorax, or Respiration: Respiratory depression

Skin: After topical application: Primary irritation 		AIHAAP 19,171,1958
skin
rabbit 		lethal dose (50 percent kill): 134 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		AIHAAP 19,171,1958


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 27 mg/kg/30 day- intermittent Cardiac: EKG changes not diagnostic of above

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 1,7,1994
oral
rat 		lowest published toxic dose: 1.825 mg/kg/26 week- intermittent Behavioral: Change in motor activity (specific assay)

Blood: Changes in leukocyte (WBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		GISAAA 1,7,1994
oral
rat 		lowest published toxic dose: 18.25 mg/kg/26 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases GISAAA 1,7,1994
oral
rat 		lowest published toxic dose: 5,145 mg/kg/21 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 1,323 mg/kg/21 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 1,323 mg/kg/21 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 1,323 mg/kg/21 week- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 2,646 mg/kg/21 week- intermittent Liver: Other changes

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		NTIS** #PB96-211735
oral
rat 		lowest published toxic dose: 200 mg/kg/10 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB94-155009
oral
rat 		lowest published toxic dose: 500 mg/kg/10 day- intermittent Behavioral: Fluid intake

Liver: Changes in liver weight 		NTIS** #PB94-155009
oral
rabbit 		lowest published toxic dose: 420 mg/kg/14 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB94-201183
oral
rabbit 		lowest published toxic dose: 700 mg/kg/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB94-155009
skin
rabbit 		lowest published toxic dose: 500 µL/kg/5 day- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0557376


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 ppm (2 mg/m3), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 ppm (2.3 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 ppm (2.3 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (2.6 mg/m3), JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.5 ppm (2 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 ppm (2.3 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 2 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BENZENETHIOL-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4092;
Number of Industries 1;
Total Number of Facilities 24;
Number of Occupations 2;
Total Number of Employees Exposed 879;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-




RTECS Compound Description:
   Reproductive Effector
   Primary Irritant