The Registry of Toxic Effects of Chemical Substances

Benzene, trimethyl - (mixed isomers)


RTECS #: DC3220000

CAS #: 25551-13-7

UPDATE: October 2002 MW: 120.21 MF: C9H12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Methylxylene
  2. Trimethyl benzene (ACGIH:OSHA)
  1. Trimethyl benzene (mixed isomers)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 28ZPAK -,24,1972
skin
rabbit 		500 mg/24 hour moderate 28ZPAK -,24,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 8,970 mg/kg N/R 28ZPAK -,24,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (120 mg/m3) DTLVS* 3,269,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (120 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (120 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (125 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (123 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (120 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 25 ppm (120 mg/m3), short term exposure limit 40 ppm (200 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 20 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average), 100 mg/m3, MAC(short term exposure limit) 170 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 25 ppm (120 mg/m3), KTV 35 ppm (170 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM LTEL 25 ppm (125 mg/m3), short term exposure limit 35 ppm, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TRIMETHYL BENZENE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1303;
Number of Industries 2;
Total Number of Facilities 198;
Number of Occupations 2;
Total Number of Employees Exposed 790;
Total Number of Female Employees Exposed 365


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.




RTECS Compound Description:
   Primary Irritant