International Chemical Safety Cards

ENFLURANE

ICSC: 0887

2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane
Ethrane
C₃H₂ClF₅O / CHF₂OCF₂CHClF
Molecular mass: 184.50
ICSC # 0887
CAS # 13838-16-9
RTECS # KN6800000

TYPES OF HAZARD/ EXPOSURE	ACUTE HAZARDS/ SYMPTOMS	PREVENTION	FIRST AID/ FIRE FIGHTING
FIRE	Not combustible. Gives off irritating or toxic fumes (or gases) in a fire.		In case of fire in the surroundings: all extinguishing agents allowed.
EXPLOSION

EXPOSURE
•INHALATION	Drowsiness. Unconsciousness. Weakness.	Ventilation.	Artificial respiration if indicated. Refer for medical attention.
•SKIN			Rinse skin with plenty of water or shower.
•EYES		Safety goggles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then take to a doctor.
•INGESTION	(See Inhalation).	Do not eat, drink, or smoke during work.	Do NOT induce vomiting. Rest. Refer for medical attention.

SPILLAGE DISPOSAL

STORAGE

PACKAGING & LABELLING

Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Absorb remaining liquid in sand or inert absorbent and remove to safe place. (Extra personal protection: self-contained breathing apparatus).

Keep in a well-ventilated room.

R:
S:

SEE IMPORTANT INFORMATION ON BACK

ICSC: 0887

Prepared in the context of cooperation between the International Programme on Chemical Safety & the Commission of the European Communities (C) IPCS CEC 2002. No modifications to the International version have been made except to add the OSHA PELs, NIOSH RELs and NIOSH IDLH values.

International Chemical Safety Cards

ENFLURANE

ICSC: 0887

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A

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PHYSICAL STATE; APPEARANCE:
CLEAR COLOURLESS LIQUID , WITH CHARACTERISTIC ODOUR.

PHYSICAL DANGERS:

CHEMICAL DANGERS:
The substance decomposes on heating or producing toxic and corrosive fumes (hydrogen chloride, hydrogen fluoride, phosgene).

OCCUPATIONAL EXPOSURE LIMITS:
TLV: 75 ppm; 566 mg/m³ (as TWA) A4 (ACGIH 1997).
OSHA PEL: none
NIOSH REL: C 2 ppm (15.1 mg/m³) 60-minute *Note: REL for exposure to waste anesthetic gas.
NIOSH IDLH: No data

ROUTES OF EXPOSURE:
The substance can be absorbed into the body by inhalation of its vapour.

INHALATION RISK:
A harmful contamination of the air can be reached very quickly on evaporation of this substance at 20°C.

EFFECTS OF SHORT-TERM EXPOSURE:
The substance may cause effects on the liver at narcotic concentrations. Exposure to vapour could cause lowering of consciousness.

EFFECTS OF LONG-TERM OR REPEATED EXPOSURE:

PHYSICAL
PROPERTIES

Boiling point: 56.5°C
Relative density (water = 1): 1.52
Solubility in water: poor

Vapour pressure, kPa at 20°C: 23.3
Relative vapour density (air = 1): 6.4

ENVIRONMENTAL
DATA

N O T E S

Other names: Anesthetic compound no. 347; NCS-115944; Alyrane; Efrane.

ADDITIONAL INFORMATION

ICSC: 0887	ENFLURANE
(C) IPCS, CEC, 2002

IMPORTANT LEGAL NOTICE:

Neither NIOSH, the CEC or the IPCS nor any person acting on behalf of NIOSH, the CEC or the IPCS is responsible for the use which might be made of this information. This card contains the collective views of the IPCS Peer Review Committee and may not reflect in all cases all the detailed requirements included in national legislation on the subject. The user should verify compliance of the cards with the relevant legislation in the country of use. The only modifications made to produce the U.S. version is inclusion of the OSHA PELs, NIOSH RELs and NIOSH IDLH values.